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P3‐322: Baseline memory performance as a predictor of neurocognitive outcome of first‐episode late‐onset depression
Author(s) -
Zhang Na,
Wang Xiao,
Li Huiying,
He Yi,
Yu Xin,
Wang Huali
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1765
Subject(s) - neurocognitive , geriatric depression scale , psychology , depression (economics) , neuropsychology , verbal fluency test , dementia , cognition , neuropsychological test , recall , mini–mental state examination , trail making test , effects of sleep deprivation on cognitive performance , audiology , psychiatry , clinical psychology , medicine , cognitive impairment , disease , depressive symptoms , economics , cognitive psychology , macroeconomics
Background: There is high comorbidity of depression and cognitive impairment in the elderly, and it would be important to explore the relationship between cognitive decline and late-life depression. This study was designed to prospectively explore the neurocognitive outcome of first-episode lateonset depression (LOD) at 6-month follow-up interval, and to explore the potential predictors of cognitive decline. Methods: Forty-nine LOD patients were recruited at Dementia Care & Research Center, Peking University Institute of Mental Health. Thirty-one with remission completed the neurocognitive examination at 6-month follow-up. A comprehensive neuropsychological test was administered at baseline and follow-up, including general cognitive function (measured with mini-mental state examination (MMSE) and cognitive abilities screening instrument (CASI)), memory (immediate object memory, 5-min delayed recall of objects, 30-min delayed recall of objects, logical memory, visual copy and recall), and executive function (verbal fluency, trail making test-A). The severity of depression was rated with geriatric depression scale (GDS-30). Subjects were imaged with a 3.0-Tesla whole-bodyMRI system and FLAIR images were acquired for the measurement of white matter hyper intensity (WMH). The polymorphism of ApoE gene was derived with PCR-RFLP. According to the GDS and MMSE score at follow-up the subjects were classified into cognitively stable group (GDS < 9, MMSE > 26, n1⁄418) and cognitively progressive group (GDS < 9, MMSE < 26, n1⁄413). Results: The score of MMSE and total score of CASI of cognitively progressive group were significantly lower than cognitively stable group (P< 0.05). Relative to cognitively stable group, the performance of immediate object memory, 5-min delayed recall of objects, 30-min delayed recall of objects, visual copy and recall were significantly poorer in cognitively progressive group (P < 0.05). In the multivariate model, the score of immediate object memory test at baseline was inversely associated with the cognitive progression among late-onset depression (OR1⁄40.31, 95% CI1⁄40.13-0.70). Conclusions: Late-onset depressive patients with poorer immediate memory performance may be at greater risk of cognitive decline.