Premium
P3‐310: The LIFE cognition study: A multicenter trial of physical activity to prevent cognitive decline
Author(s) -
Williamson Jeff,
Sink Kaycee,
Jennings Janine,
Espeland Mark,
Hendrie Hugh,
Verghese Joe,
Lopez Oscar,
Rapp Stephen,
Pahor Marco,
Miller Michael
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1752
Subject(s) - dementia , physical therapy , cognition , medicine , cognitive decline , randomized controlled trial , gerontology , physical medicine and rehabilitation , psychological intervention , cognitive training , intervention (counseling) , psychiatry , disease , surgery , pathology
against dementia and cognitive decline. The objective of this study is to determine: (1) the feasibility for MCI and early AD patients to adhere to a cardiac rehabilitation exercise program; and (2) if there are benefits to patient physical function, cognition, and mood associated with participation in a cardiac rehabilitation exercise program. Methods: We will recruit 40 peoplewithMCI or early AD from the 15-year ongoing Sunnybrook Dementia Study. Thus, we will leverage the longitudinal characterization of patients including extensive neuropsychological and imaging data. Participants will partake in the standard 6-month cardiac rehabilitation program at the Toronto Rehabilitation Institute, which incorporates a progressive, individualized aerobic and resistance exercise program in addition to social support and education regarding vascular risk factor control. Our comprehensive test battery will include measures of adherence (in clinic and at home), physical function, neurobehavioral function (cognition, mood, apathy), and indicators for cost-effectiveness modeling (health resource utilization, health-related quality of life). We will administer the complete battery before, in the middle of (at 3 months), and after the 6-month cardiac rehabilitation program and before and after a 6-month follow up period. Results: Preliminary pilot data indicates that 30% of cardiac rehabilitation participants have cognitive impairment. Adherence to the cardiac rehabilitation program is not significantly different between those with and without cognitive impairment (66.6% versus 73.1% respectively, p1⁄40.365), suggesting that cardiac rehabilitation will be feasible for people with MCI or early AD. Study enrollment will begin in mid-March. Preliminary results will be presented. Conclusions: Positive results from this trial would support expanding cardiac rehabilitation–an established, widely available program–to service people with MCI or AD, which would enable quick translation of research into clinical practice to potentially benefit this growing patient group.