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IC‐P‐160: The neural correlates of verbal episodic memory encoding in prodromal probable Alzheimer's disease at the stage of amnestic mild cognitive impairment: An fMRI study
Author(s) -
Dannhauser Thomas,
Shergill Sukhi,
Walker Zuzana
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.174
Subject(s) - episodic memory , psychology , semantic memory , posterior cingulate , audiology , memory impairment , prodromal stage , verbal memory , neural correlates of consciousness , cognition , neuroscience , cognitive impairment , medicine
tissue volumes were assessed with linear regression, adjusted for relevant confounders. Results: Higher CT-assessed calcification load in all vessel beds was associated with worse cognitive scores in all domains. Adjustment for total brain volume attenuated these associations, except for the associations between extracranial and intracranial carotid artery calcifications and motor speed in men. A higher load of extracranial carotid artery calcifications in men and intracranial carotid artery calcifications in women was significantly associated with smaller total brain volume and smaller white matter volume. In women, aortic calcifications were strongly associated with smaller grey matter volume. Calcifications in any vessel bed were not associated with hippocampal volume. Adjustment for cardiovascular risk factors or carotid plaque did not change these associations. Conclusions: A higher arterial calcification load is associated with worse cognitive function. Furthermore, calcification load in specific vessel beds is associated with smaller total brain volume, white matter volume and grey matter volume. The association between arterial calcification load and cognitive function is partly mediated by its effect on brain tissue volumes.