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P3‐271: The relationship between educational attainment and the rate of cognitive decline in elderly Canadians depends on how one scores the 3MS: The Canadian study of health and aging (CSHA)
Author(s) -
Mukherjee Shubhabrata,
Gibbons Laura,
Kristjansson Elizabeth,
Crane Paul
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1712
Subject(s) - educational attainment , psychology , goal attainment scaling , item response theory , cognition , cognitive decline , test (biology) , demography , population , gerontology , psychometrics , clinical psychology , medicine , dementia , psychiatry , pathology , disease , sociology , economics , biology , economic growth , paleontology , intervention (counseling)
age-group may confer a different etiology. Yet, little is known regarding the prevalence and risk factors for dementia which becomes manifest in the 9 decade of life or later, particularly in non-Caucasians. The goal of the present study was to determine the prevalence and risk factors for dementia at age > 90 in a large, diverse, population (N1⁄43376). Methods: Risk factors (diabetes, depression, cardiovascular disease {CVD}, osteoporosis, stroke) were collected from January 1, 1990-January 1, 2000 from electronic medical records in a group of 3376 patients of Kaiser Permanente of Northern California. Mean age in 2000 was 92.4 (standard deviation 2.51, range 90-104), 66% female, and 15% non-Caucasian . Incident dementia cases were obtained from diagnoses in primary care (general or unspecified dementia) neurology (Alzheimer’s disease vascular dementia) from January 1, 2000June 26, 2010. Cox proportional hazard models adjusted for age, gender race were calculated to evaluate the risk of dementia in association with predictors, while censoring for death, or lag in health planmembership. Results: 1329 (39%) developed dementia during the 10 year follow-up period. Prevalence was higher among females (41.8 %) versus males (34.6%) African-Americans (41.7%) versus Caucasians (39.2%), and those age 9094 (40.5%) versus those age 100+ (30.1%). Adjusted models showed those with a stroke (Hazards Ratio {HR}1⁄41.34, 95% Confidence Interval {CI}, 1.1, 1.5), depression (HR1⁄41.27, 95% CI, 1.1,1.4) or CVD (HR1⁄41.15, 95 % CI, 1.03, 1.3) at baseline had an increased risk of dementia. Diabetes and osteoporosis were not significantly associated with risk of dementia. Conclusions: In this population, cumulative prevalence of dementia among those > 90 years was almost 40%. Those with depression, CVD, or stroke had a 15-34% increased risk of dementia over the next ten years. Further studies are needed to identify predictors in this group that is most vulnerable to dementia.