Premium
P3‐176: The fourth element hypothesis of Alzheimer's disease pathogenesis
Author(s) -
Kuljis Rodrigo
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1617
Subject(s) - neuroscience , glutamatergic , compartmentalization (fire protection) , neurodegeneration , disease , gabaergic , biology , cell type , medicine , cell , glutamate receptor , pathology , genetics , receptor , biochemistry , inhibitory postsynaptic potential , enzyme
ing/Abeta generation and the activities of BACE1 and gamma-secretase. Furthermore, we investigated the levels of SNX family members in the brain of patients with AD or other neurodegenerative diseases.Results:We found that some SNX family members can regulate intracellular trafficking of BACE1 and gamma-secretase and thus affect APP processing for Abeta generation. Moreover, we found that the levels of certain SNX family members were altered in the brain of neurodegenerative disease patients when compared to control samples. Conclusions: Our results suggest that certain SNX members regulate intracellular trafficking of BACE1 and gamma-secretase and participate in the pathogenesis of AD and other neurodegenerative diseases.