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IC‐P‐147: Age‐related neural changes associated with memory functioning
Author(s) -
Chong Catherine,
Liu Seban,
Purcell Michael,
Mulligan Brendan,
Baxter Leslie
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.161
Subject(s) - functional magnetic resonance imaging , psychology , audiology , fusiform gyrus , fusiform face area , neuroscience , episodic memory , parahippocampal gyrus , temporal lobe , hippocampal formation , amygdala , prefrontal cortex , lateralization of brain function , cognitive psychology , cognition , medicine , face perception , perception , epilepsy
the CVLTand were scanned with T1-weighted magnetic resonance imaging (MRI). A three-dimensional cortical pattern matching technique was applied and segmented gray matter maps were used to calculate cortical thickness at each surface point. In terms of memory, linear regression models were used to examine the associations between learning (i.e., total number of items recalled over learning trials 1-5), short-delayed free recall, long-delayed free recall, and cortical thickness. In regard to strategy use, linear regression models evaluated the relationships between clustering at learning, clustering at the short delay, clustering at the long delay and cortical thickness. We controlled for multiple comparisons with permutation analysis, using a threshold of p < 0.01. Results: We found significant positive associations between cortical thickness and all CVLT-II indices except for semantic clustering at learning. Cortical thickness associations with longdelayed free recall (left pcorrected 1⁄4 0.013, right pcorrected 1⁄4 0.015) and semantic clustering at the long-delayed free recall (left pcorrected 1⁄4 0.014, right pcorrected 1⁄4 0.014) were stronger than those with short-delayed free recall (left pcorrected 1⁄4 0.016, right pcorrected 1⁄4 0.04) and semantic clustering at the short-delayed free recall (left pcorrected 1⁄4 0.02, right pcorrected 1⁄4 0.058; Figure 1, 2nd and 3rd row). Conclusions: Our data suggests that long-delayed free recall in normal elderly individuals is highly correlated with cortical thickness in the expected direction. The almost identical pattern of associations between long-delayed free recall and semantic clustering at the long-delayed free recall and cortical thickness suggests that strategy use greatly facilitates successful long-delayed free recall in cognitively normal elderly. IC-P-147 AGE-RELATED NEURAL CHANGES ASSOCIATED WITH MEMORY FUNCTIONING