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P3‐111: Involvement of objective memory loss in the rapid evolution from mild cognitive impairment to Alzheimer's disease
Author(s) -
Marcos Alberto
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1551
Subject(s) - memory impairment , episodic memory , neuropsychology , cognitive impairment , california verbal learning test , memory clinic , psychology , verbal memory , alzheimer's disease , audiology , cognition , medicine , disease , psychiatry
Background: The aim of the study was to demonstrate differences in the clinical evolution of patients, from mild cognitive impairment (MCI) according to Petersen criteria (2001) or taking into account an objective memory test (California Verbal Learning Test, CVLT), to Alzheimer’s Disease (AD) (according NINCS-ADRDA criteria, 1984).Methods:A prospective, longitudinal study was carried out in Clinico Hospital, Madrid, Spain from May 2008 to December 2009.We recruited 55MCI subjects. The neuropsychological assessment included MMSE, GDS, CVLTand Blessed scale. We excluded: DSM-IV, ICD-10 or secondary dementias, GDS>3, Hachinski>4 and Yesavage>9. Results: In the initial assessment, 33 patients scored below the cut-off point specified in the memory test, and 22 above. Considering the whole group, 61’9% maintains the MCI diagnosis and 38’1% developed AD after a median follow-up of 20months. However, if we divide them according towhether or not memory loss, we found that in the memory impaired group, 18 (54.5%) progress to AD in a median follow-up of 12.6 months (4.9), compared to those without memory problems, in which only 3 (13, 6%) progress to AD (mean of 11.7 months (6.4)). Conclusions: Patients diagnosed of MCI and with objective verbal episodic memory deficits, have 4 times more risk of fast-progression to AD thanMCI without objective memory impairment. We stress the need to include episodic memory items among diagnostic criteria for MCI, according to the current trend.