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P3‐106: High CSF tau predicts rapid decline to Alzheimer's type dementia in MCI subjects with abnormal CSF Aß1‐42
Author(s) -
Rossum Ineke,
Burns Leah,
Scheltens Philip,
Soininen Hilkka,
Wahlund LarsOlof,
Hampel Harald,
Tsolaki Magda,
Minthon Lennart,
Verhey Frans R.J.,
L'Italien Gilbert,
Van der Flier Wiesje,
Teunissen Charlotte,
Blennow Kaj,
Wolz Robin,
Visser Pieter Jelle
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1546
Subject(s) - dementia , medicine , atrophy , hazard ratio , memory clinic , apolipoprotein e , alzheimer's disease , cognitive impairment , psychology , gastroenterology , disease , confidence interval
patients (conversion to AD during follow-up). Data will be analyzed by means of survival analysis. We here present preliminary results of 100 patients as follow-up, data collection and data analyses are still running. The final dataset will be presented at the ICAD meeting in July 2011. Results: Preliminary data analysis comprises 50 stable MCI patients and 50 progressive MCI patients. The mean follow-up period is respectively 18,7 (12,0) months and 25,6 (17,8) months. The two groups differed significantly in MFS total scores and the MFS item score ‘loss of insight and judgment’. Mean MFS total score was 1,98 for stable MCI and 2,70 for progressive MCI patients. Multivariate analysis showed an increased risk of 59% for developing AD by each raise of one point on the MFS total score. Also, age increase of 1 year was linked to an increased risk of 42% for developing AD. Conclusions: The presence of frontal lobe symptoms inMCI showed to have an impact on the risk of conversion to AD. Consequently, these symptoms may have a prognostic value. Likewise, other behavioral symptoms should be investigated on their potential prognostic value.