Premium
P3‐104: Behavioral symptoms in mild cognitive impairment as compared to Alzheimer's disease and healthy elderly
Author(s) -
Van der Mussele Stefan,
Le Bastard Nathalie,
Vermeiren Yannick,
Saerens Jos,
Somers Nore,
Marien Peter,
Goeman Johan,
De Deyn Peter,
Engelborghs Sebastiaan
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1544
Subject(s) - dementia , psychosis , psychology , anxiety , depression (economics) , pathological , alzheimer's disease , population , disease , medicine , psychiatry , environmental health , economics , macroeconomics
Background: Mild cognitive impairment (MCI) is a clinical concept that categorizes subjects who are in an intermediate cognitive state between normal aging and dementia. The aim of this study is to characterize behavior in MCI compared with Alzheimer’s disease (AD) and healthy older patients. Design: A cross-sectional analysis of baseline data from a prospective, longitudinal study on behavioral symptoms of dementia and MCI was performed. The study population consisted of 270 MCI, 402 AD patients, and 108 healthy controls. Behavioral assessment was performed by means of Middelheim Frontality Score, Behavioral Pathology in Alzheimer’s Disease Rating Scale, Cohen-Mansfield Agitation Inventory, and Cornell Scale for Depression in Dementia. Results: Moderate-to-severe behavioral symptoms were present in 13% of MCI patients, as compared with 39% in AD patients and 3% in controls (p<0.001). The general severity of behavioral symptoms was intermediate between controls and AD patients. The three most frequent symptoms in MCI patients were aggressiveness (49%), affective disturbance (45%), and anxiety (38%); in AD patients, the most frequent symptoms were aggressiveness (60%), activity disturbances (54%), and psychosis (40%). The prevalence and severity of frontal lobe symptoms, aggressiveness, activity disturbances, and delusionswasintermediatebetweennormalagingandAD.Inaddition,theseverityofphysicallynon-aggressive and verbally agitated behavior and the severity of depressive symptoms were also intermediate. Conclusions: The behavioral profile of MCI patients is characterized as an intermediate state between normal aging and AD for the prevalence and severity of certain behavioral symptoms. Follow-up is ongoing to test the hypothesis that behavioral disturbances in MCI predict progression to dementia. Copyright # 2012 John Wiley & Sons, Ltd.