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P3‐086: Performance‐based and self‐rated everyday functioning in persons with mild cognitive impairment
Author(s) -
Lin Feng,
Roiland Rachel,
Vandenbergh Shelly,
Edwards Dorothy,
Gleason Carey,
Heidrich Susan
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1526
Subject(s) - everyday life , psychology , activities of daily living , dementia , cognition , clinical psychology , cognitive skill , population , cognitive impairment , developmental psychology , gerontology , medicine , psychiatry , disease , environmental health , pathology , political science , law
(aMCI) e4 carriers from non-carriers. Methods: Blood samples were collected to determine APOE genotype. Fifty aMCI patients were stratified into the aMCI-e4+ (n1⁄425) and aMCI-e4(n1⁄425) groups and compared to the early-stage AD group (n1⁄422). We used a standard neuropsychological battery (Unified Data Set) and an experimental computer test of visual memory binding (Episodic-like MemoryTest, EMT) which required subjects to remember spatial positions and temporal orders of series of pictures in three successive levels of difficulty (with 3, 5 and 7 items). Results: The e4+ and e4aMCI groups did not differ in basic characteristics (p’s > .27) except for gender and depression score (p’s < .01). In one-way analysis of covariance controlling for gender and depression score, we found that the aMCI e4 carriers (compared to the e4 non-carriers) had lower scores in EMT 5-item (p < .01) and 7-item (p < .05) subtests, but not in the 3-item subtest (p1⁄4.14). The aMCI e4 carriers were similar to the AD group in all EMT subtests (p’s > .48). There were no differences between e4 carriers and non-carriers in other neuropsychological tests (p’s > .15). Conclusions: We found a more profound visual memory binding deficit in aMCI e4 carriers than non-carriers. The deficit in e4 carriers resembled that found in the early-stage AD group. Memory binding represent a promising area with respect to identifying individuals at higher risk for AD in the heterogeneous MCI population.