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P3‐083: The clinical, behavioral and cognitive correlates to the proportional impact of white matter hyperintensities in the patients with amnestic mild cognitive impairment in Korea
Author(s) -
Ku Bon,
Chung Park Key,
Na Duk
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1523
Subject(s) - hyperintensity , dementia , cognitive impairment , medicine , neuropsychology , audiology , white matter , cardiology , cognition , psychology , magnetic resonance imaging , physical medicine and rehabilitation , psychiatry , radiology , disease
Background: White matter hyperintensities (WMH) are frequently observed in the elderly people and have raised cognitive impairment in patients with dementia. However there has been little attention to the proportional impact of WMH to the patients with amnestic mild cognitive impairment (aMCI). We investigated the impact of WMH to the neuropsychological profiles in patients with aMCI.Methods:We recruited patients with aMCI from April 2005 to October 2010 from 41 dementia clinics across South Korea. The participants completed a comprehensive neuropsychological test, magnetic resonance imaging (MRI), and structured medical neurological and laboratory evaluations. OnMRI, deep white matter (DWM) hyper intensities was classified into D1 (the longest diameter of DWM lesion < 10 mm), D2 (10mm1⁄4DWM1⁄424mm), and D3 (25mm < DWM). Perventricular white matter (PWM) hyper intensities was classified into P1 (caps or rim < 5 mm), P2 (between P1 and P3), and P3 (10 mm< caps or rim). The patients were divided into three categories as minimal (D1P1, D1P2, D2P1), moderate (D1P3, D2P1, D2P2, D2P3, D3P1, D3P2) and severe (D3P3) WMH. Results: A total 1374 patients were recruited as a minimal WMH group of 1090 (79.3%), a moderate of 263 (19.1%) and severe of 21 (1.5%). Mean score of MMSE was 24.663.6 and that of CDR-SOB was 1.661.0. Advanced age was significant contributors ofWMH in patients with aMCI. After adjustment of age, the neuropsychological correlates of the proportional impact ofWMHwere executive speed, frontal function, naming and verbal memory recognition profiles, and the most powerful correlates is the correct color reading of stroop test. Conclusions: We suggest that the neuropsychological correlates to the proportional impact of WMH is similar to that of patients with Alzheimer’s disease or sub cortical vascular dementia.