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P3‐076: Semantic clustering and hippocampal atrophy in mild cognitive impairment and Alzheimer's disease
Author(s) -
Hwang Kristy,
Woo Ellen,
Green Amity,
Wright Matthew J.,
LaRocca Michael,
Thompson Paul,
Apostolova Liana
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1516
Subject(s) - free recall , recall , cluster analysis , california verbal learning test , hippocampal formation , psychology , atrophy , semantic memory , recall test , semantic dementia , cognition , association (psychology) , verbal learning , dementia , cognitive psychology , neuroscience , artificial intelligence , medicine , disease , computer science , frontotemporal dementia , psychotherapist
as having MCI. This difference resulted from; higher rates of objective cognitive impairment in NESB participants; rates of functional impairment and SCC did not differ between the groups. Multiple regression results showed that NESB participants were three times more likely to be classified as having MCI than ESB participants. Demographic (age, gender and education) and acculturation (percentage of English spoken during the day) factors appeared to account for the relationship between MCI and NESB. Clinical and medical factors did not appear influential. Similar proportions of NESB and ESB participants classified as having MCI at baseline developed dementia after two years; however, a lower proportion of NESB participants with MCI reverted to normal. Conclusions:NESB participants were more likely to be classified as having MCI than ESB participants, because of poorer English skills. However, the classification was more stable in NESB participants over time, and the conversion rates for ESB and NESB participants from MCI to dementia did not differ. Classification of objective cognitive impairment was difficult in participants from NESB. Caution should be taken when using formal cognitive tests to establish impairment in individuals from NESB for the purpose of diagnosing MCI.