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P3‐068: Incidence, prevalence and predictors of course of mild cognitive impairment: The sydney memory and ageing study
Author(s) -
Brodaty Henry,
Heffernan Megan,
Kochan Nicole,
Reppermund Simone,
Slavin Melissa,
Draper Brian,
Trollor Julian,
Kang Kristan,
Sachdev Perminder
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1507
Subject(s) - dementia , medicine , incidence (geometry) , neuropsychology , epidemiology , clinical dementia rating , pediatrics , population , gerontology , disease , cognition , psychiatry , demography , audiology , physics , sociology , optics , environmental health
dementia progression. MMSE derived thresholds had higher sensitivity (MMSE 96.5% vs. A-MCI 89.9%) with little difference in specificity (MMSE 61.7% vs. A-MCI 63.6%). Both groupings were associated with similar neuropathological profiles that included Alzheimer’s pathological features (neurofibrillary tangles and plaques) and vascular disease. Conclusions: In population-based studies identification of individuals at a high risk of dementia can be as accurately achieved using a simple screening tool such as the MMSEwhen compared to more detailed A-MCI criteria. Even highly refined criteria do not identify single neuropathological phenomena in this population based study.