Premium
P3‐043: Potentiation of depolarization‐induced glutamate release in young FAD mutant hAPP mice
Author(s) -
Sokolow Sophie,
Luu Sanh,
Tseng Kelly,
Gylys Karen
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1482
Subject(s) - glutamatergic , glutamate receptor , depolarization , nmda receptor , biology , endocrinology , medicine , long term potentiation , receptor , biochemistry
control levels between 24 and 36 weeks. The hemosiderin staining was limited to vascular boundaries, most commonly within phagocytes. By 36 weeks of treatment, the gaps found in both the smooth muscle and collagen layers in affected vessels returned to control levels. Conclusions: Our data indicate that during VAB clearance by immunotherapy, microhemorrhage increases over baseline levels but is transient and resolves on a time-course that is consistent with normalization of vessel integrity.