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IC‐P‐081: Near‐infrared spectroscopy: a reliable tool to assess cortical changes in Alzheimer's disease and their progression over time
Author(s) -
Zeller Julia,
Polak Thomas,
Fallgatter Andreas
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.147
Subject(s) - prefrontal cortex , verbal fluency test , posterior parietal cortex , neuroscience , medicine , functional near infrared spectroscopy , neuroimaging , cortex (anatomy) , psychology , cardiology , cognition , neuropsychology
the VFT subjects displayed a typical activation pattern in the DLPFC with a distinct increase in O2Hb. Subjects’ lateralisation did not correlate with age. The amount of lateralisation during the letter version could account for a significant amount of the changes in MMST (16%) and DemTect (9%) after one year. Subjects displaying less distinct or no lateralisation showed a decrease in neuropsychological performance whereas subjects with a clearly lateralized activation did not change in MMSTor DemTect. Conclusions: fNIRS seems to be a suitable tool for the study of long term changes in elderly subjects when assessing brain activation and cognitive decline. As alternations in oxygenation probably occur even before atrophy in affected brain regions, fNIRS could add to the development of methods for the early detection of mild cognitive impairment or Alzheimer’s disease.