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O3‐06‐05: Physical activity, including waking, in relation to cognitive decline in women with cerebrovascular disease or vascular factors
Author(s) -
Vercambre MarieNoel,
Grodstein Francine,
Manson JoAnn,
Stampfer Meir,
Kang Jae Hee
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1428
Subject(s) - cognitive decline , cognition , verbal fluency test , cohort , demography , medicine , population , cognitive test , gerontology , dementia , psychology , disease , neuropsychology , psychiatry , environmental health , sociology
decline. Methods: Longitudinal data were analysed on 12,470 participants from the Medical Research Council Cognitive Function and Ageing Study. Subjects were aged 65 years and over and were followed up over a 16 year period. Cognition was assessed using the Mini-Mental State Examination, which was split into three groups (no impairment, slight impairment, and moderate to severe impairment). Multi-state models were used to test the associations between the cognitive lifestyle components and cognitive decline. In addition to forward transitions (cognitive decline) and transitions from all cognitive states to death, a back transition (cognitive recovery) was allowed from the slightly impaired state to the non-impaired state. Results: Higher educational attainment and a more complex mid-life occupation were associated with: a reduced hazard of a transition from a non-impaired to a slightly impaired state (hazard ratios 0.40 and 0.58, respectively); an increased chance of cognitive recovery from a slightly impaired state (3.41 and 2.90); and an increased hazard of the transition to death from a severely impaired state (1.31 and 1.17). The effect of occupation was slightly attenuated upon adjustment for education. The association between social engagement and cognitionwas independent of educational attainment and occupation; more active individuals had a decreased hazard of the transition from a slightly impaired state to a moderately/severely impaired state (0.72). Conclusions: In conclusion, increased education, late-life social engagement, and a more complex occupation independently protect from cognitive decline, enhance the possibility of cognitive recovery, but accelerate the transition to death from severe impairment. These findings support the possibility that contributions to reserve can be made across the lifecourse and that these may affect cognitive change in later life.