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P2‐505: Oral vaccine using viral vectors for Alzheimer's disease: PIB/PET studies in old cynomolgus monkeys
Author(s) -
Tabira Takeshi,
Matsumoto Shinei,
Tsukada Hideo,
Nakamura Shinichiro,
Hatano Kentaro
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1376
Subject(s) - medicine , saline , pathology , virology
dissolved in phosphate-buffered saline strongly evokes the antibody response to phage particles. 2) This response was dependent on MyD88 signaling. 3) A few copies of Abeta42 fibril mimotope-displaying phage clone induce anti-Abeta42 conformer antibody response in C57BL/6 and J20 mice Conclusions: B6-phage may provide a promising vaccination strategy for immunotherapy of Alzheimer’s diseasewithout the involvement of Abeta42-specific T cell immunity since the safety of bacteriophage for human has been investigated in a number of studies of phage therapy.