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P2‐501: Novel roles of Thalidomide in Alzheimer's disease
Author(s) -
Shen Yong,
He Ping,
Li Rena
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1372
Subject(s) - neurodegeneration , neuroinflammation , tumor necrosis factor alpha , proinflammatory cytokine , receptor , medicine , alzheimer's disease , thalidomide , pharmacology , immunology , disease , inflammation , multiple myeloma
Ci+Cew 0.6. For all these complexes, no significant difference in incorporation was observed between K562 cells and K562/ADR cells overexpressing P-gp or when the cells were depleted in energy or in the absence of mitochondrial membrane potential. Conclusions: The complexes studied here are not P-gp substrate. Their intracellular accumulation is not energy dependent and they are not accumulated into the mitochondria. In conclusion, most of the bis(thiosemicarbazones) complexes studied here could potentially cross easily BBB.