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P2‐356: Aβ accumulation correlates with cognitive decline: results from the longitudinal AIBL study
Author(s) -
Villemagne Victor,
Ellis Kathryn,
Chetelat Gael,
Bourgeat Pierrick,
Jones Gareth,
Martins Ralph,
Salvado Olivier,
Ames David,
Masters Colin,
Rowe Christopher
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1232
Subject(s) - cognitive decline , dementia , neuropsychology , medicine , longitudinal study , cohort , cognition , ageing , gerontology , psychology , disease , pathology , psychiatry
a positive family history (FH+) and/or those with high amyloid burden (PiB+) demonstrated impaired deactivation of the posterior cingulate during successful encoding compared to individuals with no family history (FH-) and low amounts of amyloid burden (PiB-). An exploratory whole brain factorial analysis investigating the group effects confirmed our ROI analysis indicating the posterior cingulate (BA 31) as demonstrating a significant (p 1⁄4 0.005) difference between the low risk (FH-/PiB-) and high risk (FH+/PiB+) groups. Conclusions: These results suggest that both parental history and amyloid deposition are risk factors influencing default network activity during memory encoding, and lend further support to the hypothesis that early brain alterations are detectable prior to clinical manifestations of AD. References: 1. Xu, G., et al., Brain, 2009. 132(2): p. 383-391. 2. Sperling, R.A., et al., Neuron, 2009. 63(2): p. 178-188 3. Vannini, P., et al., Neurobiol Aging, 2011, E-pub ahead of printing.