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P2‐355: Increased amyloid deposition and parental history of Alzheimer's disease is related to altered default network activity during successful encoding in cognitively normal older adults
Author(s) -
Vannini Patrizia,
Hedden Trey,
McLaren Donald,
Maye Jackie,
Ward Andrew,
Sullivan Caroline,
Olson Lauren,
Becker John,
Johnson Keith,
Sperling Reisa
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1231
Subject(s) - posterior cingulate , episodic memory , pittsburgh compound b , psychology , default mode network , alzheimer's disease , analysis of variance , family history , neuroscience , functional magnetic resonance imaging , disease , audiology , medicine , cognition
and late life (age 68) (aSES) in a healthy sample without dementia. We hypothesize that cSES will influence late life brain volume. Specifically, we hypothesize that cSES will influence the size of regional brain structures, including the hippocampus.Methods:We followed up volunteers born in 1936 who had participated in the Scottish Mental Survey of 1947, when they sat the Moray House Test (MHT), a test of mental ability. In a follow-up study, a subgroup (N 1⁄4 320) was invited to undergo MRI examination; 250/320 (77%) agreed to MRI and 248 satisfactory image datasets were obtained. Exploratory structural equation modelling was performed. The model is summarized in Figure 1. Briefly, cSES has a direct effect on education (EDU), aSES and brain volume (hippocampal or total brain volume). The model also has indirect effects EDU and aSES. The model also adjusts for the influence of childhood intelligence (MHT) and sex. We examined two models; Model A exploring the predictors of hippocampal volume and Model B exploring the predictors of whole brain volume. Results:Table 1 shows the regression weights for models A and B. Model A shows a significant association between the cSES and hippocampal volume after adjusting for MHT, OCC, SEX and EDU. Model B shows that none of the hypothesized causal variables have a significant influence on total brain volume. In both cases, the model provided an excellent fit to the data. Conclusions: We have shown a significant association between cSES and hippocampal volumes in late life. This result is consistent with the proposal that early life conditions have a profound effect on brain structural and function. Here, we find evidence that these effects persist for more than 50 years. Table 1 The regression weights for each causal affect in the model. FO – Father occupation, PR – Number of public rooms in the childhood home, SAN – Sanitation in the family home, MHT – Moray House Test score, cSES – Childhood socioeconomic status, SEX – gender, EDUeducation (in years), aSES –Adult socioeconomic status, DI –Deprivation index, OCC–Occupation classification, HIP – latent hippocampal volume, LHV – Left Hippocampal volume, RHV Right hippocampal volume, BV – Brain volume *p<.05