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P2‐346: Myelin integrity mediates age‐related slowing in cognitive processing speed in a sample of healthy elderly men
Author(s) -
Lu PoHaong,
Lee Grace,
Raven Erika,
Khoo Theresa,
Tingus Kathleen,
Mintz Jim,
Thompson Paul,
Bartzokis George
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1223
Subject(s) - white matter , cognition , corpus callosum , psychology , audiology , population , myelin , medicine , neuroscience , magnetic resonance imaging , central nervous system , environmental health , radiology
concerned the subiculum (r1⁄4 0.64; p< 10-5), a slighter effectwas found for CA1 (r 1⁄4 0.36; p 1⁄4 0.004), whereas the other subfields were spared (r 1⁄4 0.02; p 1⁄4 0.90). Subicular volume positively correlated to WM density in the posterior CC, the cingulum bundle and the fornix (Figure b). This association was still significant when controlling for age. No significant correlation was found for CA1 nor the Other subfields. Conclusions: We showed that with aging, WM undergoes extensive changes encompassing frontal but also limbic areas. Besides, WM density in limbic areas is correlated to the shrinkage of the subiculum, the major hippocampal output sending fibres through the fornix and to the retrosplenial cortex. It is thus likely that age-related alterations in the subiculum and in these WM tracts are related, and together participate to the impairment of a common brain network.