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IC‐P‐053: Age‐associated memory impairment is associated with greater rate of longitudinal brain atrophy
Author(s) -
Lu PoHaong,
Lee Grace,
Hua Xue,
Leow Alex,
Melchor Stephanie,
Toga Arthur,
Jack Clifford,
Weiner Michael,
Thompson Paul
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - Spanish
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.122
Subject(s) - audiology , psychology , atrophy , alzheimer's disease neuroimaging initiative , dementia , cognition , neuroimaging , cognitive decline , recall , cognitive impairment , neuroscience , medicine , disease , cognitive psychology
N 105 203 159 98 63 116 85 Age in years 75.7 (5.2) 75.4 (7.3) 74.5 (7.0) 71.1 (7.3) 76.8 (5.7) 75.1 (6.6) 78.0 (7.1) <0.0001 Gender % male 51% 66% 60% 58% 83% 54% 69% <0.0001 Converters % 38% 48% 36% 59% 0.01 ApoE4 carrier % 20% 45% 69% 59% 46% 53% 61% 0.2 MMSE 29.1 (1.0) 27.2 (1.8) 26.7 (1.7) 27.2 (1.8) 26.9 (1.8) 27.1 (1.9) 26.6 (1.6) 0.2 CSF biomarkers Tau (baseline) y 69 (28) 93 (54) 114 (53) 92 (46) 80 (38) 110 (57) 119 (63) 0.01 P-tau (baseline) y 24 (13) 31 (17) 41 (17) 34 (18) 29 (13) 39 (18) 38 (18) 0.02 Abeta1-42 (baseline) y 209 (54) 175 (59) 145 (40) 166 (61) 156 (49) 166 (53) 154 (50) 0.6