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P2‐336: Left medial temporal volumes and FCSRT cut off scores could be future complementary tools to predict dementia in healthy elderly.
Author(s) -
Bernard Charlotte,
Amieva Hèlène,
Dilharreguy Bixente,
Helmer Catherine,
Dartigues JeanFrancois,
Allard Michèle,
Catheline Gwénaëlle
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1213
Subject(s) - psychology , laterality , voxel , audiology , recall , free recall , population , cognitive psychology , developmental psychology , medicine , radiology , environmental health
CVLTalso measures the memory strategy of "semantic clustering"one’s ability to organize information to be learned into their superordinate categories to facilitate recall.Methods: 42 cognitively normal elderly (NC) subjects underwent detailed cognitive testing including the CVLTand were scanned with T1weighted magnetic resonance imaging (MRI). A three-dimensional cortical pattern matching technique was applied and segmented gray matter maps were used to calculate cortical thickness at each surface point. In terms ofmemory, linear regression models were used to examine the associations between learning (i.e., total number of items recalled over learning trials 1-5), short-delayed free recall, long-delayed free recall, and cortical thickness. In regard to strategy use, linear regression models evaluated the relationships between clustering at learning, clustering at the short delay, clustering at the long delay and cortical thickness. We controlled for multiple comparisons with permutation analysis, using a threshold of p< 0.01. Results:We found significant positive associations between cortical thickness and all CVLT-II indices except for semantic clustering at learning. Cortical thickness associations with long-delayed free recall (left pcorrected1⁄4 0.013, right pcorrected1⁄4 0.015) and semantic clustering at the long-delayed free recall (left pcorrected 1⁄4 0.014, right pcorrected 1⁄4 0.014) were stronger than those with short-delayed free recall (left pcorrected 1⁄4 0.016, right pcorrected 1⁄4 0.04) and semantic clustering at the short-delayed free recall (left pcorrected 1⁄4 0.02, right pcorrected 1⁄4 0.058; Figure 1, 2 nd and 3 row). Conclusions: Our data suggests that long-delayed free recall in normal elderly individuals is highly correlated with cortical thickness in the expected direction. The almost identical pattern of associations between long-delayed free recall and semantic clustering at the long-delayed free recall and cortical thickness suggests that strategy use greatly facilitates successful long-delayed free recall in cognitively normal elderly.