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P2‐228: The role of multivesicular bodies in Alzheimer's disease
Author(s) -
Edgar James,
Cheetham Michael,
Futter Clare
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1111
Subject(s) - endosome , microbiology and biotechnology , endocytic cycle , extracellular , chemistry , amyloid precursor protein , senile plaques , population , intracellular , amyloid precursor protein secretase , endocytosis , biology , alzheimer's disease , biochemistry , cell , medicine , disease , environmental health
Methods: In order to determine the relationship between ongoing neuronal activity, synaptic plasticity and isoform composition of extracellular Abeta, electrophysiologal and biochemical methods had been utilized. Results: Our results show that Abeta40 and Abeta42 isoforms were differentially affected by low-frequency single spikes versus high-frequency spike bursts. Dynamics of [Abeta40]o correlated to short-term plasticity of synaptic vesicle release, displaying facilitation during bursts. Ongoing neuronal activity negatively regulated burst-evoked facilitation of [Abeta40]o and long-term potentiation of vesicle release in hippocampal synapses. Notably, [Abeta42]o exhibited weaker dependency on the pattern of neuronal and synaptic activity. Conclusions: These results suggest that temporal pattern of activity critically controls Abeta40/Abeta42 ratio and propose that the history of synaptic activation regulates metaplasticity of Abeta40 and synaptic vesicle release in hippocampal networks.