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P2‐210: Activation of TLR‐4 receptors by Par‐4 in neuronal degeneration in Alzheimer's disease
Author(s) -
Xie Jun,
Guo Qing
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1093
Subject(s) - neurodegeneration , microbiology and biotechnology , receptor , biology , programmed cell death , signal transduction , alzheimer's disease , neuroscience , apoptosis , biochemistry , medicine , disease
receptor activation. Moreover, autophagy and lysosomal pathway seem to be involved in As effects. Preincubation of cells with microalgae oil protected retinal cells from As cytotoxicity. Conclusions: P2X7 cell death receptor seems to be an interesting therapeutic target for beta-amyloid-induced degenerative diseases. Docosahexanoic acid modulates P2X7 receptor activation. So, associated to others P2X7 inhibitor, DHA has interesting biological properties which open new perspectives in therapeutics applications.