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P2‐166: Walking in late middle age and prevalence of dementia in centenarians in the monzino 80‐plus study
Author(s) -
Tettamanti Mauro,
Recchia Angela,
Garrì Mariateresa,
Riva Emma,
Nobili Alessandro,
Pasina Luca,
Franchi Carlotta,
Lucca Ugo
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1052
Subject(s) - dementia , medicine , mood , stroke (engine) , observational study , population , incidence (geometry) , gerontology , demography , disease , physical therapy , psychiatry , environmental health , mechanical engineering , physics , optics , sociology , engineering
the 3MS (adjusted odds ratio (AOR) 1⁄4 2.37, 95% confidence interval (CI) 1.16, 4.87). This association remained significant after further adjustment for degree of hypoxia (defined as the % of sleep time with SpO2 < 90%). Women with greater night time wakefulness had more than twice the odds of impaired verbal fluency (vegetable naming) (AOR 1⁄4 2.17, 95% CI 1.10, 4.28). There was a trend toward an association between elevated night time wakefulness and brief delayed recall (verbal memory) (AOR 1⁄4 1.83, 95% CI 0.94, 3.54). We observed no association between total sleep time and cognitive outcomes after accounting for greater night time wakefulness and potential confounders. Conclusions: Among very old women, sleep fragmentation, as manifested by greater night time wakefulness, is independently associated with impaired performance on tests of general cognitive function and verbal fluency, after accounting for sleep duration. Exploratory analyses suggest that the association between fragmented sleep and general cognitive function is independent of hypoxemia.