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P2‐160: A high burden of vascular disease increases the risk of mild cognitive impairment: the mayo clinic study of aging.
Author(s) -
Roberts Rosebud,
Geda Yonas,
Knopman David,
Cha Ruth,
Boeve Bradley,
Pankratz V.,
Rocca Walter,
Petersen Ronald
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1046
Subject(s) - medicine , hazard ratio , interquartile range , population , confidence interval , apolipoprotein e , cohort , proportional hazards model , prospective cohort study , disease , environmental health
rological parameters of theMOUS scale (Single domainsOccupational Useful Score), was another objective. A cross sectional, national epidemiological study was set up. Investigators were asked to include 8 patients. They completed a questionnaire with MMSE, the diagnostic criteria apathy, diagnostic criteria for depression and comorbidity scale (CIRS). Patients completed a self-administered questionnaire, including inventory Apathy, Geriatric Depression Scale (GDS) and MOUS. Results: 734 patients were enrolled by 115 physicians. Patients were predominantly female (62%), with an age of 80 years (SD 1⁄4 6.6 years). Average MMSE was 23 (min 20-max 29). 41.6% (296) of patients completed the set of diagnostic criteria ’s apathy and 52.7% (381) had apathy clinical symptoms. 47,9% (340) of patients had a depression diagnosis. Patients with apathy had a lower average MMSE than patients without apathy (22.7 versus 23.4) and IADL scores lowest detection (2.5 vs. 3) and therefore (1.9 versus 2.6). They received more social assistance (APA)(22.4% versus 10.6%). 32.4% (225) of patients had both apathy and depression. 8.8 % (65) of patients had apathy alone, 14.6 % (107) depression alone and 40,6 %(298) neither apathy nor depression. These 4 groups of patients were different regarding age, social level, APA, age of diagnosis, MMSE, IADL and comorbidities. Concerning the MOUS scale, all domains were different between the 4 groups. Internal consistency was 0.697. Conclusions: The observed frequency of apathy and depression was 41.6%, respectively (n 1⁄4 296) and 47.9% (n 1⁄4 340). Typology of patients based on the presence or the combination of apathy and depression showed significant differences. Acknowledgment: ESTIME GROUP Support from: EISAI, PFIZER