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P2‐135: Progression of MRI markers and decline of cognitive performance over 10 years the 3C‐MRI‐Dijon study
Author(s) -
Godin Ophélia,
Tzourio Christophe,
Maillard Pauline,
TzourioMazoyer Nathalie,
Crivello Fabrice,
Mazoyer Bernard,
Kaufman Jay,
Dufouil Carole
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1021
Subject(s) - atrophy , medicine , hyperintensity , neuropsychology , brain size , cognitive decline , cognition , cardiology , magnetic resonance imaging , population , dementia , disease , radiology , psychiatry , environmental health
exposures were baseline bodymass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). We used the Western Australian Data Linkage System to establish the presence of new cases of dementia between 1996 and 2009 according to the International Classification of Diseases. Crude and adjusted hazard ratio (HR, 95% confidence interval, 95%CI) of dementia for each adiposity marker was calculated using Cox regression models. Other measured factors included age, marital status, education, alcohol use, smoking, fat consumption, physical activity, and prevalent diabetes, dyslipidaemia and cardiovascular disease. Results: Compared with men with BMI < 25, participants with BMI between 25-30 had lower adjusted HR of dementia (HR 1⁄4 0.83, 95% CI 1⁄4 0.72-0.97). The HR of dementia for men with BMI 1⁄4 30 was comparable to men with BMI < 25 (HR 1⁄4 0.85, 95%CI1⁄4 0.70-1.05). Waist circumference showed no obvious association with dementia hazard.MenwithWHR1⁄4 0.9 had lower adjusted HR of dementia than men with WHR< 0.9 (HR1⁄4 0.82, 95%CI1⁄4 0.68-0.98). We found a “J” shape association betweenmeasures of obesity and the hazard of dementia, with the nadir of risk being in the overweight range of BMI and about 1 for WHR. Conclusions: Higher adiposity is not associated with incident dementia in older men. Overweight men and those with WHR 1⁄4 0.9 have lower hazard of dementia than men with normal weight and withWHR < 0.9.