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P2‐122: Time scales for time‐to‐event analyses of Alzheimer's studies
Author(s) -
Betensky Rebecca,
Blacker Deborah,
Sperling Reisa,
Johnson Keith
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.1010
Subject(s) - disease , biomarker , subclinical infection , time point , hazard ratio , scale (ratio) , proportional hazards model , medicine , association (psychology) , statistics , psychology , confidence interval , mathematics , biology , biochemistry , philosophy , psychotherapist , aesthetics , physics , quantum mechanics
ipants underwent yearly neuropsychological testing for up to 7 years (2002-2009), with their cognitive status (presence and type of dementia) adjudicated based on clinical and imaging data. Prevalent cardiovascular disease status was determined at the time of entry into the CHS. Noninvasive vascular studies collected during the course of CHS (19881998) included: Ankle-Arm Index, Coronary calcium (CCa) score, and MRI white matter grade. Slope of the Modified Mini Mental State (3MS) examination assessed yearly from 1988-98 was calculated for each participant. Kaplan Meir survival curves were generated to determine cumulative survival to dementia among different groups. Results: 210 of the 445 participants developed dementia during the observation period. ApoE*4 status (HR 1.3[CI 1.0, 1.8]), age at the baseline visit (> 79, (HR 2.3 [CI 1.3, 4.1]), and the 3MS score at baseline (< 90 (HR 2.1 [1.3, 3.1]) increased the risk of developing dementia during follow up. Dementia (including AD) developed more rapidly as a function of having an AnkleArm Index below 0.9, higher CCa score and steeper slope of decline on 3 MS prior to diagnosis. The presence of hypertension, diabetes, orMRI white matter grade were not related to time to develop dementia or AD. Conclusions: In an elderly cohort, markers of peripheral vascular disease were associated with an accelerated progression to Alzheimer’s dementia and dementia of all causes.