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IC‐P‐136: Estimation of total intracranial volume; a comparison of methods
Author(s) -
Ridgway Gerard,
Barnes Josephine,
Pepple Tracey,
Fox Nick
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.099
Subject(s) - atrophy , white matter , grey matter , neuroimaging , brain size , alzheimer's disease neuroimaging initiative , statistical parametric mapping , psychology , nuclear medicine , medicine , neuroscience , pathology , disease , magnetic resonance imaging , alzheimer's disease , radiology
Total intracranial volume is a useful measure of inter-subject variability in pre-morbid brain volume, which has been recommended for inclusion in region of interest and voxel-based morphometric studies of dementia [1]. TIV can be estimated from structural MRI using time-consuming manual tracing or using automated methods. We show that recent improvements to the Statistical Parametric Mapping (SPM) software's unified segmentation method allow highly accurate and unbiased estimates to be obtained rapidly and without interaction.