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IC‐P‐117: A comparative study of voxel and surface‐based cortical thickness methods in frontotemporal dementia
Author(s) -
Clarkson Matthew,
Cardoso Jorge,
Modat Marc,
Ridgway Gerard,
Leung Kelvin,
Rohrer Jonathan,
Ourselin Sebastien,
Fox Nick
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.082
Subject(s) - voxel , grey matter , dementia , white matter , frontotemporal dementia , semantic dementia , medicine , vertex (graph theory) , audiology , magnetic resonance imaging , artificial intelligence , laplace operator , nuclear medicine , pattern recognition (psychology) , mathematics , radiology , computer science , pathology , disease , mathematical analysis , combinatorics , graph
brain in contrast to wild type, suggesting that APs could be detected by DPC tomography. In order to confirm those observations, brains were sectioned after the DPC scans and subjected to Thioflavine-S staining, followed by two-photon imaging. Both signals were highly correlated, demonstrating that the set-up was indeed detecting APs. Finally, local DPC tomography of the 5xFAD brain was performed at the level of the hippocampus. The high resolution obtained allowed us to visualize the structure of APs. Conclusions: We demonstrated that DPC tomography could be used to detect APs across the entire brain of a transgenic mouse model of AD at a high resolution, without using any contrast agents. This new tool yields AP structural details, including size and morphology. Future researches, directed towards reducing the X-ray dose, will reveal if DPC tomography could be applicable to in vivo imaging.