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IC‐P‐090: Corrected Cerebral Flow Reserve from Brain SPECT as a Marker of Dementia Risk
Author(s) -
Pretorius Harold,
Richards Nichole,
Menke Dennis,
Kelly Jerome,
Idoine John,
Haste Shelley,
Pagani Luis
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.056
Subject(s) - medicine , dementia , cerebral blood flow , cardiology , depression (economics) , diabetes mellitus , liraglutide , nuclear medicine , endocrinology , disease , type 2 diabetes , economics , macroeconomics
Background: Mixed Dementia (including Alzheimer’s) risk may be increased by hypertension (BP), diabetes mellitus (DM), waist-height ratio (WH), traumatic brain injury (TI), thyroid (Td), renal (Rd), pituitary (Pd) disease and depression (De). To study dementia pathogenesis we developed a brain SPECT measure of cerebral flow reserve (CFi) with correction factors due to decreased tracer clearance in Rd.