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IC‐P‐008: Characteristics of brain morphology in dementia patients from an ADRC
Author(s) -
Becker James,
Teverovsky Leonid,
Aizenstein Howard,
Butters Meryl,
Price Julie,
Klunk William,
Lopez Oscar
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2011.05.025
Subject(s) - white matter , brain morphometry , lateral ventricles , medicine , dementia , brain size , skull , cardiology , nuclear medicine , radiology , anatomy , magnetic resonance imaging , disease
the left rolandic operculum, precentral and postcentral gyri, superior temporal gyrus, middle cingulum, and inferior parietal lobule, while patients with nonfluent PPA experienced atrophy of the left superior frontal gyrus, inferior temporal gyrus, anterior/middle cingulum, and bilateral amygdala. The direct comparison between the two patient groups showed that CBS-nonfluent patients had a greater atrophy of the left rolandic operculum, postcentral gyrus, and inferior parietal lobule compared with nonfluent PPA. On the contrary, patients with nonfluent PPA had a greater tissue loss of the left superior frontal gyrus, inferior temporal gyrus, and bilateral amygdala compared with those with the CBS-nonfluent variant. Conclusions: Our findings corroborate the overlap between nonfluent PPA and CBS. This study also suggests that specific anatomical substrates are associated with different clinical symptoms in these patients. The damage to the left insula in all patients highlights its role in motor speech deficits, while the parietal damage is likely to be related to limb apraxia.