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P4‐131: Consumption of Hydrogen Water Prevents the Age‐dependent Impairment in Learning and Memory Tasks in AD Model Mice
Author(s) -
Ohsawa Ikuroh,
Nishimaki Kiyomi,
Murakoshi Hiroe,
Yokota Takashi,
Ohta Shigeo
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.08.190
Subject(s) - neurodegeneration , oxidative stress , chemistry , morris water navigation task , hydrogen , ischemia , endocrinology , medicine , neuroscience , biochemistry , psychology , cognition , organic chemistry , disease
Background: Nicotinamide adenine dinucleotide (NAD) metabolism has been implicated in aging and age-dependent neurological disorders; while the NAD+/NADH ratio decrease during aging process, it remains unknown whether the increase of this ratio could reverse aging-related phenotypes due to the lack of drug to increase NAD+/NADH ratio in vivo. Methods: Three groups of APP/PS1 mice (6 month-old) were reared with different diet programs,control (normal diet, ad libitum), CR (70% of normal diet), and bL-supplemented food (60mg /kg/day),respectively. After 6 months of dietary treatments, we conducted behavioral assays. Results: The administration of bL in APP/PS1 mice for six months recovered the learning capacities. Mice with bL-diet showed the increased metabolic rates with robust morphology of mitochondria in the brain and muscles. Conclusions: These results support the role NAD metabolism plays a critical role in aging process and age-dependent disorders and suggest that NQO1-dependent production of NAD+ can be an useful strategy for the prevention and cure of aging-dependent dementia and Alzheimer’s disease.