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P4‐050: TOMM40 Variable Length Polymorphism is Associated With Memory Function in Asymptomatic Middle‐aged Persons
Author(s) -
Sager Mark A.,
La Rue Asenath,
Johnson Sterling C.,
Saunders Ann M.,
Roses Allen D.,
Koscik Rebecca,
Jonaitis Erin,
Lutz Michael W.,
Asthana Sanjay,
Green Robert C.,
Hermann Bruce P.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.08.110
Subject(s) - asymptomatic , population , apolipoprotein e , genotype , genotyping , psychology , audiology , medicine , genetics , biology , disease , gene , environmental health
A TOMM40 polymorphism, a variable length intronic poly T repeat (rs10524523), has been shown to influence age of Alzheimer’s disease (AD) onset (Roses et al., 2009). In this study, we tested the hypothesis that subjects homozygous for TOMM40 short poly T sequences <21 (SPT) would show better performance on measures of learning and memory than those who were homozygous for longer poly T sequences ≥21 (LPT) in middle-aged subjects enrolled in WRAP.