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P4‐016: Chronic Treatment With Nicotine or the Selective α7 nAChR Agonist PNU‐282987 does not Alter Amyloid‐β Levels in Tg2576 Mice
Author(s) -
Hajos-Korcsok Eva,
Sly Laurel M.,
Chin Jia-En
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.08.076
Subject(s) - nicotine , agonist , nicotinic agonist , hippocampus , nicotinic acetylcholine receptor , pharmacology , chemistry , medicine , endocrinology , acetylcholine receptor , receptor
relationship between serum UA and cerebral ischemia as presenting white matter hyperintense (WMH) signals on T2-weighted brain magnetic resonance images (MRI). We estimated WMH by Clinical Research Center for Dementia of South Korea (CREDOS) rating scale. Results: We made three categorization in cerebral WMH as mild, moderate, severe by CREDOS scale. In 173 patients there were no significant differences in serum UA in cerebral WMH between three groups. However, Serum UA showed different mean values within AD patients (ANOVA, p 1⁄4 0.025). In post hoc analysis, serum UAwas significantly high in “severe” WMH. We carried out multiple logistic regression analysis, only hypertension showed statistically significant correlations with cerebral WMH. Conclusions: These findings showed that serum UA did not show significant correlation with whitematter changes, after controlling age, sex, hypertension, diabetes and other pro-, anti-oxidants. Hypertension was the only significant variable in association with cerebral ischemia in patient with AD.