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P4‐009: Characterisation of Depression in Dementia and Mild Cognitive Impairment
Author(s) -
Le Bastard Nathalie,
Bekelaar Kim,
Elseviers Monique,
Van Buggenhout Michael,
Mariën Peter,
Saerens Jos,
Somers Nore,
De Deyn Peter Paul,
Engelborghs Sebastiaan
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.08.069
Subject(s) - depression (economics) , dementia , psychology , depressive symptoms , multivariate analysis , neuropsychology , neuropsychological test , alzheimer's disease , medicine , disease , cognition , psychiatry , clinical psychology , economics , macroeconomics
Background: Baseline data-analysis of a prospective Belgian study was performed to characterise significant depressive symptoms and its behavioural correlates in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) patients. Methods: 200 AD (189 probable and 11 definite AD patients) and 200 MCI patients were included and behavioural and neuropsychological data were obtained using a standard battery of assessment scales and tests. Statistical analysis consisted of Mann Whitney U test for comparison of data between groups and univariate analysis. Multivariate analysis was used to develop models that accounted for the variation of depressive symptoms. Results: MCI patients showed less behavioural symptoms and were less cognitively impaired than AD patients. MCI/AD patients with significant depressive symptoms showed significantly more behavioural symptoms than patients without significant depressive symptoms. Depressive symptoms were correlated with almost all BPSD tested in AD and MCI patients. For MCI patients, a model with three behavioural symptoms (verbally agitated behaviour, physically non-aggressive behaviour, diurnal rhythm disturbances) was developed that accounted for 53,7% of variation of depressive symptoms. For AD patients a model with three behavioural symptoms (frontal lobe symptoms, delusions and diurnal rhythm disturbances) was developed that accounted for 40,7% of variation of depressive symptoms. Conclusions: Several behavioural symptoms were correlated with depressive symptoms in MCI and AD. A model was developed that accounted for 52,1% and 46,1% of variation in depressive symptoms in MCI and in AD, respectively. The occurrence of diurnal rhythm disturbances urge to screen for depression in bothMCI and AD patients.