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P4‐002: Involvement of the Kynurenine Pathway in Alzheimer's Disease
Author(s) -
Guillemin Gilles J.,
Rahman Abdur,
Ting Ka Ka,
Cullen Karen,
Braidy Nady,
Chung Roger,
Wu Wei,
Brew Bruce J.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.08.063
Subject(s) - quinolinic acid , phosphorylation , kynurenine pathway , glutamate receptor , western blot , nmda receptor , immunocytochemistry , serine , biology , immunohistochemistry , kynurenic acid , human brain , medicine , chemistry , receptor , endocrinology , microbiology and biotechnology , neuroscience , kynurenine , biochemistry , amino acid , immunology , tryptophan , gene
aMCI and mdMCI. MCI cohort exhibited decreased PET Z-scores (all p < 0.001) in PCC, MPC, PAC, and TAC relative to the normal database; visual cortex (control) Z-scores did not differ between groups. MPC Z-scores differed among MCI subtypes (p 1⁄4 0.006), with aMCI (p < 0.05) and mdMCI (p < 0.05) exhibiting lower Z-scores than naMCI; however, MPC Z-scores did not differ between aMCI and mdMCI. Conclusions: Fornix integrity and medial parietal cortical glucose metabolism, as measured by neuroimaging, can differentiate amnestic from non-amnestic subtypes of MCI.