P4‐002: Involvement of the Kynurenine Pathway in Alzheimer's Disease | Zendy

Guillemin Gilles J. | Zendy; Rahman Abdur | Zendy; Ting Ka Ka | Zendy; Cullen Karen | Zendy; Braidy Nady | Zendy; Chung Roger | Zendy; Wu Wei | Zendy; Brew Bruce J. | Zendy

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P4‐002: Involvement of the Kynurenine Pathway in Alzheimer's Disease

Author(s) -

Guillemin Gilles J.,

Rahman Abdur,

Ting Ka Ka,

Cullen Karen,

Braidy Nady,

Chung Roger,

Wu Wei,

Brew Bruce J.

Publication year - 2010

Publication title -

alzheimer's and dementia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.713

H-Index - 118

eISSN - 1552-5279

pISSN - 1552-5260

DOI - 10.1016/j.jalz.2010.08.063

Subject(s) - quinolinic acid , phosphorylation , kynurenine pathway , glutamate receptor , western blot , nmda receptor , immunocytochemistry , serine , biology , immunohistochemistry , kynurenic acid , human brain , medicine , chemistry , receptor , endocrinology , microbiology and biotechnology , neuroscience , kynurenine , biochemistry , amino acid , immunology , tryptophan , gene

aMCI and mdMCI. MCI cohort exhibited decreased PET Z-scores (all p < 0.001) in PCC, MPC, PAC, and TAC relative to the normal database; visual cortex (control) Z-scores did not differ between groups. MPC Z-scores differed among MCI subtypes (p 1⁄4 0.006), with aMCI (p < 0.05) and mdMCI (p < 0.05) exhibiting lower Z-scores than naMCI; however, MPC Z-scores did not differ between aMCI and mdMCI. Conclusions: Fornix integrity and medial parietal cortical glucose metabolism, as measured by neuroimaging, can differentiate amnestic from non-amnestic subtypes of MCI.

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