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Harmonization of magnetic resonance‐based manual hippocampal segmentation: A mandatory step for wide clinical use
Author(s) -
Frisoni Giovanni B.,
Jack Clifford R.
Publication year - 2011
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.06.007
Subject(s) - protocol (science) , segmentation , harmonization , hippocampal formation , computer science , task (project management) , gold standard (test) , magnetic resonance imaging , task force , measure (data warehouse) , artificial intelligence , medical physics , medicine , data mining , neuroscience , pathology , radiology , psychology , engineering , alternative medicine , physics , systems engineering , public administration , acoustics , political science
Hippocampal atrophy is a marker of disease state and progression in Alzheimer's disease. The gold standard to measure hippocampal volume is through manual segmentation. A number of protocols to measure hippocampal volume through manual segmentation have been developed, but the marked heterogeneity of anatomical landmarks has given rise to wide variability of volume estimates. With the aim of fostering the use of hippocampal volume in routine clinical settings, an international task force is currently working on developing a harmonized protocol that will resolve and reduce the present heterogeneity. The task force will then validate the harmonized protocol, develop harmonized probabilistic hippocampal maps, and develop illustrative and educational material on the use of the harmonized protocol and maps.