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P1‐431: Neuroimage in Alzheimer's disease: Results after plasma exchange with Human Albumin Grifols ®
Author(s) -
Roca Isabel,
Boada Mercè,
Cuberas Gemma,
Tárraga Lluís,
Muñoz Joan,
Grifols Joan Ramon,
Ortiz Pilar,
Hernández Isabel,
Buendía Mar,
Anaya Fernando,
Olazarán Javier,
Rubio Lourdes,
Torres Gustavo,
Guzmán de Villoria Juan,
Núñez Laura,
Páez Antonio,
Ferrer Isidre
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.986
Subject(s) - statistical parametric mapping , nuclear medicine , positron emission tomography , medicine , neuroimaging , alzheimer's disease neuroimaging initiative , alzheimer's disease , psychology , magnetic resonance imaging , disease , radiology , psychiatry
Further, MCI patients also showed decreased BOLD signal in the hippocampus during the delay period when compared to controls. Although MCI patients had diminished neural activity, they performed similarly to controls on the delayed yes/no recognition task. However, in a surprise, incidental longterm memory task, MCI patients reported less familiarity with the previously viewed pictures than controls. Conclusions: Taken together, these findings suggest that MCI patients were unable to adequately modulate neural activity in critical task-specific brain regions for attention and memory, and thereafter demonstrated impaired long-term memory recognition. In summary, the DLPFC and the hippocampus may be sites of early selective vulnerability in MCI patients, and that differences in neural modulation may be a potential biomarker of mild cognitive impairment.