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P1‐425: Evolution of gray matter atrophy on serial MRI scans predicting the progression from MCI to Alzheimer's
Author(s) -
Spulber Gabriela,
Niskanen Eini,
Kivipelto Miia,
Julkunen Valtteri,
Hallikainen Merja,
Vanninen Ritva,
Wahlund Lars-Olof,
Soininen Hilkka
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.980
Subject(s) - grey matter , atrophy , precuneus , voxel based morphometry , parahippocampal gyrus , middle frontal gyrus , medicine , fusiform gyrus , gyrus , voxel , postcentral gyrus , superior frontal gyrus , magnetic resonance imaging , white matter , pathology , radiology , temporal lobe , psychiatry , epilepsy , functional magnetic resonance imaging
volumes only correlated weakly to memory function (p 1⁄4 0.05). But visual rating scores of WM lesions showed no correlation with either of the cognitive domains. After VaD patients were excluded from the analysis, correlations remained significant between these two cognition domains and most of the DTI measures. The DTI correlations with the cognitive measures remained significant even after covarying for T2 lesion volumes and hippocampal volumes. Conclusions: DTI correlates with cognition better than conventional MRI in patients with SIVD. Whole brain DTI histogram may be a reliable and sensitive technique for early detection of cognitive impairment in SIVD patients and may be also useful in monitoring disease progression in these patients.