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P1‐407: A computational method to quantitate neuronal cell loss in a transgenic mouse model of Alzheimer's disease
Author(s) -
Iordanescu George,
Venkatasubramanian Palamadai N.,
Wyrwicz Alice M.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.962
Subject(s) - senile plaques , voxel , neuroscience , genetically modified mouse , support vector machine , hyperplane , artificial intelligence , neuropathology , pattern recognition (psychology) , hippocampal formation , pyramidal cell , biology , alzheimer's disease , transgene , pathology , computer science , mathematics , medicine , combinatorics , disease , biochemistry , gene
latency parameters between controls and patients, whether in the ‘on or the ‘off’ state; or between the patients in the ‘on’ and the ‘off’ state. However, there was a negative correlation between letter fluency and the variability of saccade latency, whereas no correlation was found between overall motor function and any of the latency parameters. Voxel-wise grey matter volume estimates correlated with the latency parameters in several brain areas in patients and controls (p < 0.05 FWE corrected for multiple comparisons). Shorter saccade latency positively correlated with grey matter volume in regions of the prefrontal cortex, the cerebellar vermis, and the fusiform gyrus. The variability of saccade latency negatively correlated with grey matter volume in the frontal eye fields in patients; in controls, there was a negative correlation between the variability of latency and grey matter volume of the frontal and parietal eye fields, the premotor cortex, and the lateral prefrontal cortex. Conclusions: The behavioural and imaging findings point to an association between saccade latency, executive function and the prefrontal cortex. Our findings also suggest that saccadic latency and variability are associated with atrophy within a known oculomotor network. Therefore, saccadometry may provide important information on the severity of executive dysfunction and at the same time offer a rapid and non-invasive correlate of focal brain atrophy in healthy ageing and neurodegeneration.