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P1‐404: Cortical thinning in verbal, visual and both amnestic types of mild cognitive impairment
Author(s) -
Kim Min-Jeong,
Im Kiho,
Lee Jong-Min,
Park Aram,
Kim Geon Ha,
Kim Jong Hun,
Roh Jee Hoon,
Seo Sang Won,
Na Duk L.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.959
Subject(s) - psychology , audiology , visual memory , dementia , cognitive impairment , verbal memory , pathological , memory impairment , cognition , neuroscience , medicine , disease , pathology
and corrected for multiple comparisons using the False-Discovery Rate method. Results: In all subjects with amyloid deposition, we observed local positive correlations within frontal, posterior (precuneus, parietal, temporal) and occipital cortices. In controls with amyloid deposition, we also observed weaker trans-cortical correlations between frontal and posterior regions. In MCI, the frontal-posterior correlations were much stronger and there were some occipital-posterior correlations. In AD, all of these correlations were stronger and some moderately strong correlations appeared between occipital and frontal regions. In AD there were no correlations between mesial temporal cortex and other cortical regions, while in MCI and control subjects these correlations were apparent and more marked, especially in MCI. Conclusions: The associations of amyloid deposition between cortical regions may vary with increasing cognitive (and presumably pathological) severity. Our findings suggest that the early phases of amyloid deposition are varied across the cortex and that the occipital cortex may be the last cortical region to develop heavy amyloid deposition. The weaker correlations of PiB retention in mesial temporal areas with those in other cortical areas with increasing disease severity may be due to increasing atrophy in this region.