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P1‐385: Altered visuospatial working memory process in patients with Alzheimer's disease: fMRI investigation
Author(s) -
Lee Chang- Uk,
Lim Hyun-Kook
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.939
Subject(s) - working memory , precuneus , functional magnetic resonance imaging , psychology , premotor cortex , neuroscience , fusiform gyrus , prefrontal cortex , audiology , n back , cognition , medicine , dorsum , anatomy
temporal volume was associated with approximately 1.5 times (95% CI 1.1 to 2.0) greater risk of AD. The area under the ROC curve for FreeSurfer medial temporal, LEAP hippocampal, and Ab:tau (logarithmic) were 0.688, 0.604, and 0.572, respectively. Conclusions: We found that the 3 biomarkers (hippocampal volume, medial temporal lobe volume, and CSF Ab:tau) significantly and independently predict the development of AD from MCI. A particular level of Ab:tau ratio enhances the predictive accuracy of MRI biomarkers. These biomarkers are associated with different aspects of AD pathology.