Premium
P1‐379: 1H‐MRS a valuable complement to MRI in the early diagnosis of Alzheimer's disease
Author(s) -
Westman Eric,
Wahlund Lars-Olof,
Foy Catherine,
Poppe Michaella,
Cooper Allison,
Murphy Declan,
Spenger Christian,
Lovestone Simon,
Simmons Andrew
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.933
Subject(s) - magnetic resonance imaging , multivariate statistics , multivariate analysis , hippocampus , population , alzheimer's disease , medicine , cognitive impairment , disease , psychology , pathology , nuclear medicine , radiology , mathematics , statistics , environmental health
input of the reported coordinates and the sample sizes of each study. The meta-analytical statistical threshold was set at a false discovery rate p < 0.01 and a minimum cluster extent of 100mm. Results: Ten studies met the inclusion criteria. Nine reported baseline regional gray matter (GM) atrophy in mild cognitive impairment (MCI) or healthy subjects who progressed to AD. Out of the ten studies, six included subjects with amnestic MCI (aMCI) at baseline. These studies comprised a total of 429 aMCI subjects, of which 142 converted to AD. Meta-analysis of the 31 coordinates from these six studies yielded one significant cluster of GM volumetric reduction in aMCI patients who converted to AD, located in the left hippocampus and parahippocampal gyrus (see figure). Conclusions: Atrophy in aMCI patients who convert to AD is a consistent finding across studies. Meta-analysis showed that left medial temporal lobe atrophy is the most consistent neurostructural biomarker to predict conversion from aMCI to AD.