Premium
P1‐344: Factors responsible for neurofibrillary tangle formation and neuronal cell death in tauopathy brains
Author(s) -
Shoji Mikio,
Kawarabayashi Takeshi,
Wakasaya Yasuhito,
Takamura Ayumi,
Watanabe Yukiko,
Watanabe Mitsunori
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.897
Subject(s) - tauopathy , neurofibrillary tangle , programmed cell death , biology , neurogenesis , neurodegeneration , oxidative stress , microbiology and biotechnology , doublecortin , apoptosis , neuroscience , pathology , biochemistry , dentate gyrus , alzheimer's disease , central nervous system , senile plaques , medicine , disease
Background: TgTauP301L that overexpresses mutant human tauP301L present in FTDP-17 reproduces neurofibrillary tangles (NFT), neuronal death, memory disturbance and substantial phenotypic variation. Methods: To reveal factors responsible for NFT formation and neuronal death, comparison sets of TgTauP301L with or without NFT and neuronal cell losses were studied using oligonucleotide microarrays. Results: Results indicate that alteration of gene expressions in biological pathways including oxidative stress, apoptosis, mitochondrial fatty acid betaoxidation, inflammatory response pathway, complement and coagulation cascades pathway and EGFR1pathway. Reactive increased Apolipoprotein D for NFT neurotoxicity and decreased doublecortin according to suppressed neurogenesis were observed. Conclusions: These findings indicate that NFT formations and neuronal cell losses occur under alterations of many biological pathways, especially oxidative stress, apoptosis, mitochondrial dysfunction, inflammation, cell cycle and signal transductions in tauopathy brains.