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P1‐214: Elevated iron and zinc in Alzheimer hippocampus: A postmortem study using neutron activation analysis
Author(s) -
Leite Renata E.,
Grinberg Lea T.,
Ferretti Renata E.L.,
Farfel Jose M.,
D.L. Alho Ana Tereza,
Andrade Mara P.,
Polichiso Livia,
Tampellini Edilaine,
Lima Maria C.,
Caetano-Júnior Antonio,
Oliveira Kátia C.,
Pasqualucci Carlos A.,
Nitrini Ricardo,
Jacob-Filho Wilson,
Saiki Mitiko
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.765
Subject(s) - hippocampus , postmortem studies , medicine , amyloid beta , pathology , alzheimer's disease , oxidative stress , zinc , physiology , disease , psychology , chemistry , organic chemistry
concomitant AD pathology. Findings that TL is shorter even in substantially non-mitotic brain tissue suggests that telomere shortening might in part be an innate feature of individuals, either owing to congenitally shortened telomeres, or an inherited tendency for reduction in telomere length. Additional experiments examining longitudinal decline in blood leukocyte DNA may be able to further clarify the degree to which telomere length is environmental or acquired versus innate.