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P1‐194: First report of frontotemporal dementia‐like phenotype in an argentine family with presenilin‐1 M146V Alzheimer's disease with Pick Bodies.
Author(s) -
Bartoloni Leonardo C.,
Serrano Cecilia S.,
Rojas Galeno J.Z.,
Riudavets Miguel,
Sevlever Gustavo,
Taratuto Ana Lia,
George P Hyslop St.,
Allegri Ricardo F.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.744
Subject(s) - frontotemporal dementia , presenilin , pathology , pick's disease , dementia , proband , mutation , psychology , alzheimer's disease , medicine , genetics , disease , biology , gene
IV infusion of I-labeled m266, w0.1% of the antibody was detected in the CSF and w0.18% in brain. Although m266 was present in the transgenic mouse brain, immunohistochemical studies revealed that the antibody was not associated with plaques; evidence that m266 was not directly acting to remove existing Ab deposits. Evaluation of m266 in a model that determines the rate that ADDLs are added to existing plaques further demonstrated that the antibody did not attenuate the deposition of new material in the transgenic brain. Conclusions: These data suggest that m266 was not capable of abating the formation and deposition of ADDLs in the cortex and hippocampus of transgenic mice. Data from human clinical trials will assess the impact of m266 on cognition in patients with AD.