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P1‐141: Altered core body temperature in triple transgenic (3xTgAD) Alzheimer's disease mice
Author(s) -
Allan Stuart M.,
Smith Jennifer,
Waters Elizabeth,
Knight Elysse,
Lawrence Catherine B.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.690
Subject(s) - medicine , genetically modified mouse , endocrinology , transgene , ibuprofen , chemistry , pharmacology , biochemistry , gene
Tg4510 and AD. The common pathways are: Long Term Potentiation, MAPK, Neurodegenerative Disorders, Regulation of Actin Cytoskeleton, ERBB, Notch, Calpain. Some of the common functions are: axonogenesis, apoptosis, synaptic transmission, MAPKKK cascade, phosphatase regulatory activity. 44 genes from these functional groups exhibit similar regulation in both Tg4510 and AD. 19 of these genes are associated with synapses. Gene Set Enrichment Analysis (GSEA) on 14 week mice and pre-symptomatic AD against genes that are found in networks upstream of Tau and expansion to their neighbors, showed that 70 of these genes are common between Tg4510 and AD. Conclusions: Functional analysis and comparison of microarray data from different organisms and experimental designs is an efficient way to explore for biologically significant pathways and genes. Such genes and pathways that affect Tau are common between Tg4510 and human AD.