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P1‐119: Treatment with RGS‐14 protein not only prevents but also recovers object memory loss found in ageing rats
Author(s) -
López-Aranda Manuel F.,
López-Téllez Juan F.,
Navarro-Lobato Irene,
Masmudi-Martín Mariam,
Khan Zafar U.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.668
Subject(s) - cortex (anatomy) , neuroscience , psychology , impaired memory , cognition
studied prion protein (PrP) expression effect on Abeta peptide in APPswe/ PS1dE9/PrP mice. We showed that PrP regulated positively plasma Abeta levels in tg mice. Plasma Abeta was not significantly different between young and aged mouse lemurs. Conclusions: Plasmatic Abeta detection in tg mice and mouse lemurs is a simple and very precise tool, and is modulated by genetic background and PrP expression. This tool could follow the effects of potential treatments for AD.